Diagnostic and prognostic value of neuron-specific enolase and S-100 protein in pediatric viral encephalitis

Objective – to study the dynamics of level neuron-specific enolase (NSE) and S-100 protein in blood serum cerebrospinal fluid children with various features viral encephalitis course outcome define their role diagnostics prognosis. Material methods. 48 aged from 1 month 15 years were examined. Analysis NSE was performed by method hardphase immune-enzyme analysis. Results. A reliable increase identified comparison control group both acute reconvalescence periods. During period higher values found herpesvirus etiologies varicella zoster encephalitis, during protein. In case most severe disease reliably patients condition. Children convulsive syndrome demonstrated concentration than without convulsions. formation stable neurologic deficiency there an recovered patients. It also that if >7.0 ng/ml, it possible predict unfavourable sensitivity 61.54% specificity 71.43%. The highest proteins dead patient herpes encephalitis. Conclusion. pediatric is characterized diagnostic prognostic significance, demonstrates pathogenesis can be used for therapy correction.